BEIRUT: An Israeli air strike on Damascus killed 15 people early on Sunday and badly damaged a building in a district housing state security agencies, a war monitor said.

Civilians, including two women, were among those killed in “the deadliest Israeli attack in the Syrian capital” since the civil war began, said Rami Abdel Rahman of the Syrian Observatory for Human Rights.

The overnight strike cratered a road and wrecked the adjacent 10-storey building in the Kafr Sousa district, which is home to senior state officials and Syrian intelligence headquarters, said the Britain-based Observatory.

A woman was also killed in the Mazraa district, possibly hit when Syrian anti-aircraft munitions crashed down, it added.

It was not immediately clear who was the intended target of the strike, which correspondents reported shook Damascus and left a gaping hole in the street.

Russia, Iran condemn attack; Tel Aviv asked ‘to put an end to armed provocations’ against Syria

Other missiles overnight hit a warehouse used by pro-regime Iranian and Hezbollah fighters near Damascus, said the Observatory, which relies on a wide network of sources inside Syria.

Iranian news agency Tasnim said “no Iranian was harmed”, adding that the strikes hit “exactly the spot” where Hezbollah’s top commander Imad Mughniyeh was killed in a 2008 car bombing the group blamed on Israel.

Syria’s defence ministry gave an initial death toll of five, including one soldier, and 15 wounded civilians, some in critical condition.

Shortly after midnight “the Israeli enemy carried out an aerial aggression from the direction of the occupied Golan Heights targeting several areas in Damascus and its vicinity, including residential neighbourhoods”, a statement said.

Defence forces “shot down several missiles”, it added.

Historic buildings near the medieval Damascus citadel were also “severely damaged”, said the head of the Syrian antiquities department, Nazir Awad, blaming “an Israeli missile”.

An Israeli military spokesperson said: “Israel does not comment on reports in foreign media.”

Syrian government ally Russia condemned the strike, with foreign ministry spokeswoman Maria Zakharova also urging Israel “to put an end to armed provocations” against Damascus that could endanger “the entire region”.