Pakistan News Service

Sunday Apr 20, 2014, Jumada-al-thani 19, 1435 Hijri
Logo Logo
LATEST :
Pakistan News Home -> Health -> News Details

Vitamin D Often High in Crohn's Disease Patients

15 November, 2012

  Related News  
Vitamin D deficiency may up risk of heart disease
Simple vitamin can strengthen the bones
  More on this View All

ISLAMABAD: Contrary to expectations, people with the inflammatory bowel condition Crohn's disease are likely to have excessive levels of the active form of vitamin D in their blood, researchers have found. This is associated with low bone mineral density, they report.

Dr. Maria T. Abreu from the Inflammatory Bowel Disease Center at Cedars-Sinai Medical Center in Los Angeles led the study. She told Reuters Health, "Most doctors think that Crohn's patients automatically have decreased vitamin D levels and encourage supplementation with vitamin D. We would like to urge doctors to check vitamin D levels before making that recommendation."

As Abreu's team explains in the medical journal Gut, under certain circumstances too much active vitamin D can actually contribute to the breakdown of bone, leading to osteoporosis.

The researchers found "inappropriately high" blood levels of the active form of vitamin D in 42 percent of the 138 people they studied with Crohn's disease. This was true of only 7 percent of 29 patients with ulcerative colitis, another type of inflammatory bowel disease.

Also, the higher the blood levels of active vitamin D in Crohn's patients, the lower was their bone density -- regardless of whether they were treated with steroids -- the investigators found.

"We believe that high vitamin D levels are most likely a manifestation of the underlying gut inflammation," Abreu said.

A high vitamin D level is "an additional risk factor predisposing to development of osteoporosis" for some Crohn's disease patients, the team concludes. Treatment of the underlying inflammation, "may improve metabolic bone disease."

End.

Reader Comments:

Don't these people read the literature

High levels of the active form of vitamin d in the blood is a sign of vitamin d deficiency. When the levels of 25(OH)D in the blood drop (this is the storage form) the levels of 1,25(OH)D (the active form that controls blood calcium levels) rises. Treat the vitamin d deficiency and the levels of the active from in the blood will drop.

Pete, United Kingdom - 16 November, 2012

 What do you think about the story ? Leave your comments!

Heading (Optional)
Your Comments: *

Your Name:*
E-mail (Optional):
City (Optional):
Country (Optional):
 
 
Field marked(*) are mandatory.
Note. The PakTribune will publish as many comments as possible but cannot guarantee publication of all. PakTribune keeps its rights reserved to edit the comments for reasons of clarity, brevity and morality. The external links like http:// https:// etc... are not allowed for the time being to be posted inside comments to discourage spammers.

  Speak Out View All
Artilce 6 and Musharraf Trail
Blocking Nato supply line
  Quick Vote Show Results
Question: "In view of the current situation do you think Talks with Taliban should take place only within the ambit of Article 4 of Objectives Resolution that defines our Common Purpose i.e. PM/ President down to all Pakistanis to work till we achieve the rights of Democracy, Freedom, Tolerance and Social Justice for all Pakistanis:"
Yes
No
 
Candid Corner
Exclusive by
Lt. Col. Riaz Jafri (Retd)
Drone kills 15 'Qaeda', three civilians in Yemen: security
Senior journalist Hamid Mir hurt in Karachi attack
Suggested Sites