Pakistan News Service

Sunday Jun 24, 2018, Shawwal 10, 1439 Hijri
Logo Logo
Pakistan News Home -> Health -> News Details

Gene harms brain decades before Alzheimer's outbreak

17 May, 2012

ISLAMABAD: A gene that you carry may begin to damage your brain a full 50 years before Alzheimer's disease shows up, scientists say.

In 1993, researchers discovered a gene known as ApoE4 -- carried by about a quarter of us -- that triples the risk for getting Alzheimer's.

In 2009, three more risky genes were discovered, and one of them, called clusterin or CLU, was found to up the risk of getting Alzheimer's by 16 percent.

Now, University of California Los Angeles researchers say that CLU begins to damage your brain a full 50 years before Alzheimer's shows up, the Journal of Neuroscience reports.

Paul Thompson, professor of neurology and his colleagues at California report that the C-allele of the CLU gene (one of two or more forms of a gene), impairs the development of myelin, the protective covering around the neuron's (brain cell) axons, making it more vulnerable to the onset of Alzheimer's much later in life.

Researchers scanned the brains of 398 healthy adults ranging from 20 to 30 years using a newer type of MRI that maps the brain's connections, according to a California statement.

They compared those carrying a C-allele variant of the CLU gene with those who had a different variant.

They found that young, healthy carriers of the CLU-C gene risk variant showed a distinct profile of a kind of white matter that may increase susceptibility to developing the Alzheimer's disease later in life.


 What do you think about the story ? Leave your comments!

Heading (Optional)
Your Comments: *

Your Name:*
E-mail (Optional):
City (Optional):
Country (Optional):
Field marked(*) are mandatory.
Note. The PakTribune will publish as many comments as possible but cannot guarantee publication of all. PakTribune keeps its rights reserved to edit the comments for reasons of clarity, brevity and morality. The external links like http:// https:// etc... are not allowed for the time being to be posted inside comments to discourage spammers.

  Speak Out View All
Military Courts
Imran - Qadri long march
Candid Corner
Exclusive by
Lt. Col. Riaz Jafri (Retd)
Pakistan itself a victim of state-sponsored terrorism: Qamar Bajwa
Should You Try Napping During the Workday?
Suggested Sites