Pakistan News Service

Wednesday Apr 23, 2014, Jumada-al-thani 22, 1435 Hijri
Logo Logo
LATEST :
Pakistan News Home -> Health -> News Details

Excess protein linked to Parkinson`s disease

13 February, 2013

ISLAMABAD: Overexpression of a protein can disrupt vital recycling processes in neurons leading to development of Parkinson`s disease a neurodegenerative movement disorder.

Researchers at the University of California, San Diego School of Medicine found that overexpression of the alpha-synuclein protein appears to disrupt vital recycling processes in neurons.

It starts with the terminal extensions of neurons, working its way back to the cells` center, with the potential consequence of progressive degeneration and eventual cell death.

"This is an important new insight. I don`t think anybody realised just how big a role alpha-synuclein played in managing the retrieval of worn-out proteins from synapses and the role of alterations in this process in development of PD," said principal investigator Mark H Ellisman.

Parkinson`s disease is characterised by the gradual destruction of select brain cells that produce dopamine, a neurotransmitter involved in regulating movement and emotion.

Researchers, with colleagues at the University of Illinois, Urbana, focused upon one of those gene products: alpha-synuclein.

They found that excess levels of alpha-synuclein accumulated in the presynaptic terminal - part of the junction where axons and dendrites of brain cells meet to exchange chemical signals.

"The over-expression of alpha-synuclein caused hypertrophy in these terminals. The terminals were enlarged, filled with structures we normally don`t see," said Daniela Boassa, the study`s first author.

Boassa said that as alpha-synuclein accumulates in the terminals, it appears to hinder normal degradation and recycling processes in neurons. This would progressively impair the release of neurotransmitters. In time, the neurons might simply stop functioning and die.

"Other studies have noted that PD is characterised by progressive loss of vesicle traffic, and neurotransmitter release. Our study provides a structural and mechanistic explanation for why that happens," Boassa said.

The study was published in The Journal of Neuroscience.

End.

 What do you think about the story ? Leave your comments!

Heading (Optional)
Your Comments: *

Your Name:*
E-mail (Optional):
City (Optional):
Country (Optional):
 
 
Field marked(*) are mandatory.
Note. The PakTribune will publish as many comments as possible but cannot guarantee publication of all. PakTribune keeps its rights reserved to edit the comments for reasons of clarity, brevity and morality. The external links like http:// https:// etc... are not allowed for the time being to be posted inside comments to discourage spammers.

  Speak Out View All
Artilce 6 and Musharraf Trail
Blocking Nato supply line
  Quick Vote Show Results
Question: "In view of the current situation do you think Talks with Taliban should take place only within the ambit of Article 4 of Objectives Resolution that defines our Common Purpose i.e. PM/ President down to all Pakistanis to work till we achieve the rights of Democracy, Freedom, Tolerance and Social Justice for all Pakistanis:"
Yes
No
 
Candid Corner
Exclusive by
Lt. Col. Riaz Jafri (Retd)
Drone kills 15 'Qaeda', three civilians in Yemen: security
Senior journalist Hamid Mir hurt in Karachi attack
Suggested Sites